Free Standard Shipping on ALL PremiershopMD Orders!

Obagi Tretinoin 0.1% Cream

Acne treatment cream
Topical treatment for acne vulgaris. Available by prescription only, all Obagi tretinoin formulations are non-comedogenic and fragrance free.

Prescription required. Contact your healthcare provider to purchase, or find a nearby physician who offers this product.
Call for Price
Earn 128 Premier Points
Tretinoin is the generic name for synthetic, first-generation all-trans-retinoic acid. Topical tretinoin first arrived on the dermatology scene in the 1960s. It is a prescription drug approved to treat acne, and in a few other FDA-approved products, to treat fine facial wrinkling, limited psoriasis, and other conditions.

Available in multiple strengths and formulations by prescription only, Obagi tretinoin creams and gel work deep inside the skin to treat acne.
Each gram contains:
Tretinoin 0.1%, stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water

Monica Correll

28 days ago

I have noticed that my skin looks better and my pores are much smaller.

Luisa Salazar

29 days ago

Works wonderful to smooth out any finelines and. Ery happy with the results.

Monica Joosten

1 months ago

love what this does! great product!

Karen Smilie

1 months ago

Love this stuff. Mix with blender or skin lightening cream at night. But only every 3rd night. I peel if i use this too often

Candida Manion

1 months ago

It has helped my skin tone and complexion a lor, besides the fine lines. This is enough for night

Jessica Peine

1 months ago

I recently switched to this from .05% and I love the results so far. My skin has adjusted very quickly and I plan to use this for the long run. My acne is reduced even more. I have a nice glow! Highly recommended!

Danielle Edwards

2 months ago

Miracle product. Helps with everything from acne, redness, to scarring and pores size.

Courtney Strong

4 months ago

I've used this for 3 yearsversions. I love Obagi's tret b/c it I see it is working

Adriane Ayerdis

4 months ago

Works great!

Sarah Scott

4 months ago

My skin has never been smoother!

Nerissa Murray

5 months ago

Great results and gentle on my skin

Kristen Jurado

6 months ago

Strong product, regular use produces soft more more yourhful skin!

Lindsey Gierlinski

6 months ago

Love it

ASSOUMAHU DIALLO

6 months ago

Good

Michelle McManus

7 months ago

Secret weapon to erasing brown patches

Brandie Dye

7 months ago

I swear by this product!! Ive been using this for 12yrs and cant live without!!

Jennifer Pipkin

7 months ago

Works so well and helps keep my breakouts to none.

Sally Taylor

7 months ago

Dont be afraid of the strength its wonderful Love . I tried all % i love them all

Palmer Kuder

9 months ago

This product has really improved the texture of my skin.

Jessica Winters

9 months ago

This product works great alone or with the blender from the NuDerm system. This has helped with my fines lines and will not go without it !

Mariah Vasquez

9 months ago

feels great!

Alicia Donovan

9 months ago

The fountain of youth in a tube!

Karla Mancilla

10 months ago

Best retin a ever!!!

Linds Perugini

11 months ago

Works on fine lines

Zarah Celino

1 years ago

Amazing product

Tia Wells

1 years ago

A literal miracle in a tube. I was not good to my skin in my younger years. I am now fighting to turn back time and with this in my corner I have managed to do so.

Julie Krajicek

1 years ago

Great

JC Scanlon

1 years ago

Easy to apply with dotting method. My skin has racted well to it. I apply moisturizing cream 20-30 minutes after rubbing tretinoin in.

Tina Tinoco

1 years ago

Ive been using this for years now ans always get compliments on my skin, i give credit all the credit to Obaji Trentinion cream and all my other Obaji products.

Lori Chance-Snell

1 years ago

One of my favorite products!!

Polina Farias

1 years ago

Excellent product’

Thanh Trang Thai

1 years ago

Great product!

Lara Colley

1 years ago

Use everyday for youthful skin. Mix it with Blender to get the most out of it.

Lisa Lamica

1 years ago

Seeing improvements quickly!

RayAnna Rogers

1 years ago

Love

Reyna. Medina

1 years ago

It’s the best product

Deja Eisenhour

1 years ago

I’ve used this for years. It’s a necessary product to keep that youthful look.

RavenTommy Breaux

1 years ago

Since using this product I have seen improvement in my skin! My acne has improved and I now have an overall glow. I will be purchasing again!

Jen Lee

1 years ago

The Best Tret on the Market!!

Katie Hayes

1 years ago

I have not had a peeling which my aesthetician is shocked! I’ve been on for 6 weeks and have noticed a difference

Liberty Davidson

1 years ago

Great results when used with the Blender product

Rebecca Truhe

1 years ago

This is the one product I am sure to never to go without! Love it in conjunction with Blender!

Lex Curiel

1 years ago

awesomeness

Need to Know

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

Precautions: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered.

Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.

Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin.

Tretinoin Cream should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether.

Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.

Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate.

To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

How to Use

Morning Routine:

  • Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne.

Nighttime Routine:

  • Wash with a mild soap and dry skin gently
  • Wait 20 to 30 minutes to allow skin to completely dry
  • Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation
  • Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area
  • Avoid corners of the nose, mouth, eyes, and open wounds
  • Tretinoin is for topical use, only
  • Tretinoin should be applied once daily, or as directed by physician. Please ensure to always read and follow the Patient Instruction in the Prescribing Information leaflet that accompanies your tretinoin prescription
  • Tretinoin acne treatment should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes
  • Application of excessive amounts of gel will not provide incremental efficacy
  • Store tretinoin cream at controlled room temperature below 80°F

Morning Routine:

  • Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne.

Nighttime Routine:

  • Wash with a mild soap and dry skin gently
  • Wait 20 to 30 minutes to allow skin to completely dry
  • Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation
  • Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area
  • Avoid corners of the nose, mouth, eyes, and open wounds
  • Tretinoin is for topical use, only
  • Tretinoin should be applied once daily, or as directed by physician. Please ensure to always read and follow the Patient Instruction in the Prescribing Information leaflet that accompanies your tretinoin prescription
  • Tretinoin acne treatment should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes
  • Application of excessive amounts of gel will not provide incremental efficacy
  • Store tretinoin cream at controlled room temperature below 80°F