Obagi Tretinoin 0.05% Cream

Acne treatment cream
Topical treatment for acne vulgaris. Available by prescription only, all Obagi tretinoin formulations are non-comedogenic and fragrance free.

Prescription required. Contact your healthcare provider to purchase, or find a nearby physician who offers this product.
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Tretinoin is the generic name for synthetic, first-generation all-trans-retinoic acid. Topical tretinoin first arrived on the dermatology scene in the 1960s. It is a prescription drug approved to treat acne, and in a few other FDA-approved products, to treat fine facial wrinkling, limited psoriasis, and other conditions.

Available in multiple strengths and formulations by prescription only, Obagi tretinoin creams and gel work deep inside the skin to treat acne.
Each gram contains:
Tretinoin 0.05%, stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water

Luisa Salazar

1 days ago

Love this little product and a little goes a long way in keeping my skin smooth.

Elizabeth Serrano

22 days ago

Changed a few items in my skin care

Sue Rickman

1 months ago

This product is makinc my face look so moch better! I'm loving the results!

Katie R

1 months ago

A must in your skincare routine.

Barbara Medici

1 months ago

I like it. works well.

Hilary DiFeo

2 months ago

Great

Kristi Morrrill

2 months ago

This has changed my skin for the better. I have always had large, noticable pores and this product has made my skin smooth and my pores less noticeable.

Nancy Padua

2 months ago

Wonderful product for acne

Nicolle Gentry

3 months ago

Helps collagen

Katie Waring

3 months ago

Love it

Laura Jackson

3 months ago

makes my skin look so smooth

Allison Rosenwasser

5 months ago

I switched from the gel form to the cream form of this product. Both have worked great for me

Susan Jeffcoach

5 months ago

Clears up my skin

Tina Tinoco

6 months ago

Ive been using obaji tretinoin for years so this % is not quite strong enough for me. I think it would be good for a beginner.

Danielle Capogna

7 months ago

Great

Cindy Mejia

8 months ago

This is a staple for my nightly face regimen. It is also highly recommended by dermatologist. Def must have!!

Haley White

8 months ago

Love this

Renae Brenson

9 months ago

Amazing! Got so many compliments

Megan Swanson

9 months ago

This is a staple skincare item for anyone their 30's or older. My skin looks smokther, no breakouts, reduced fine lines, and no ahe spots.

Allie Fisher

9 months ago

This product had completely changed my skin!

Carolyn Thompson

10 months ago

I have uswd obagi Tretinoin for 6 months and am amazed by the results

Geri Kenneally

10 months ago

After using 3-4 times a week for the past month my skin looks and feels fantastic!!

Kathy Maez

10 months ago

A little goes a long way. I used every other day for awhile to have my skin adjust. Brighter, clearer skin.

Leydys Fernandez

10 months ago

Works great!!

Anna Raske

11 months ago

Alexandra Jensen

11 months ago

Important addition to the line!

Sohaila Mahini

1 years ago

It works well.

Samantha Bell

1 years ago

Very strong very effective

Yolanda Riley

1 years ago

Very effective!! Love it!!

Susan Bastida

1 years ago

Couldnt go without it

Brianna Hames

1 years ago

Unsure of effectiveness as i cant use regularly because it dries my skin out way too much!

Kellie Britten

1 years ago

It works.

Amber Gentille

1 years ago

Clears up skin nicely. Beeare though you go through a phase of peeling and redness but if u push thru its so worth it. Results r incredible!!

Celeste O?Keefe

1 years ago

Great

Kristi Wilson

1 years ago

just got this and had no irritation after applying! can't wait to see results for crows feet!

Joann Cina

1 years ago

Great

Zarah Celino

1 years ago

Great product

Karen Anderson

1 years ago

F do hgg

Courtney Wolbert

1 years ago

Good product

Christine Pelic

1 years ago

Wotks great for fine lines and wrinkles. My skin looks clearer and brighter with regular use. Make sure to dry face and gradually work toward using every night to avoid peeling.

Jessica Staiger

1 years ago

I live for this! Helps with breakouts

Sara Adams

1 years ago

More even skin tone noted

Allison Zarzosa

1 years ago

Great!

Jessica Peine

1 years ago

I used this starting in March 2021, after having used Epiduo for nearly 2 years. I researched how to deal with skin adjusting to tretinoin so I could be prepared for initial side effects, and I was fine within a month. My acne has reduced even more, and my face does have a nice glow. Great product!

Monica Correll

1 years ago

I highly recommend tretinoin cream. It undoubtedly keeps my skin youthful looking.

Crystal Primm

1 years ago

I wish i could rate this 100 stars!

Merydith Vann

1 years ago

I feel like it brighting of my skin and works well with exfoliation.

Katherine LaHurd

1 years ago

This has evened out my skin tone so much!

LINDSEY MEARS

1 years ago

A staple for skincare!

Brenda Kohls Medlock

1 years ago

This little tube along with the blender is the perfect pairing against wrinkles. I get compliments on my skin often. At the age of 62...I will take them!

Princess Tucker

1 years ago

I started using this product over 6 months ago, it works wanders. . Have deen a big inprovement in my skin tone . The product is expensive but its worth it. Very pleased

Alicia Tomkin

1 years ago

So far so good. Ive been using this for about 2 months and liking the entire system a lot.

Reanee Grab

1 years ago

Worked well, but should of started with a stronger dose.

Adriane Ayerdis

1 years ago

Good for first starting off but did switch to higher percentage.

Taylor Dettman

1 years ago

This product has been a game changer for my skin! Love!!

Patty Cooper

1 years ago

Just 4 weeks in and minimal reactions. Quality product.

Bethene Newland

1 years ago

Great product

Victoria Ramon

1 years ago

wonderful!

Mylene Santos

1 years ago

Love it

Kristen Jurado

1 years ago

Great intro level, not too irritating. I was even able to ise on my neck and chest.

Megan Wieder

1 years ago

makes my skin texture so smooth!

Amanda Mahoney

1 years ago

Great product! Just the right strenght and does not dry out my skin. My wrinkles have noticably decreased!

Laura Mahoney

1 years ago

My brown spots are fading fast.

Ivana Markovic

1 years ago

Really works!!

Sally Taylor

1 years ago

This wAs my first tretinoin cream with my first obagi kit . Iove them all

Julianne Parker

1 years ago

Love it

Cathy Obrien

1 years ago

This makes a huge difference!

Ana Vega

1 years ago

Smooth application - potent

Jennifer Cockrell

1 years ago

Best retinoin ever used!

Myra Crowe

1 years ago

Na

Tiffany Keller

1 years ago

Amazing product.

Christi Rodriguez

1 years ago

Great product!

Abby Potts

2 years ago

This has changed my skin. So happy with results!

Christine Albert

2 years ago

Great. No fragrance. Great for sensitive skin

Catherine Miele

2 years ago

I also use the blender with this product. I spread it to my overall face and have seen how my skin is being exfoliated slowly. My skin has a new fresh appearance.

Ilyssa Feierstein

2 years ago

Another great product!

Mary Meek

2 years ago

This retinol cream is unlike any other! I use it every other night and as a spot treatment for any acne that comes up!

Michaela Campbell

2 years ago

This Obagi product is MUST

Raquel Balan

2 years ago

Top rated

Harleigh Peluso

2 years ago

Love it

Shelley Kluz

2 years ago

Love it!!

Rima Hammoud

2 years ago

Wow this stuff is amazing.

Nicole Strohl

2 years ago

Works great!

Beth Stewart

2 years ago

Works great

Jaclyn Zatezalo

2 years ago

Have tried the gel also, but this one free bit more hydrating. Wake up every morning with glowing skin

Satanya Clarke

2 years ago

The best

Stephanie Logan

2 years ago

A little bit goes a long way. Real the instructions and speak with your Doc. Tube usually lasts 6+months, currently pregnant and no longer using. Hopefully the product stays good :-/

Renee Kim

2 years ago

its great

Elizabeth Watkins

2 years ago

Love this product! It has cleared up my face and smoothed out my skin texture.

Amy Hansen

2 years ago

Works great and doesn’t irritate my skin.

Suvd Baljinnyam

2 years ago

Great product!

Heidi Ryan

2 years ago

Miracle worker!! Fine lines are vanishing every day. I highly recommend this to everyone who wants their youth restored. Make sure to take a before picture so you can watch the results.

Megan Culbreth

2 years ago

Love this Tretinoin! Perfect for more oily prone skin!

Nichole Grazioli

2 years ago

Love this. I can definitely feel it working. I enjoy the lower percent option and the ability to work my way to the next level.

Trish Walstead

2 years ago

A must add on to your routine!

Melinda Visser

2 years ago

Tretinoin is my favorite product. It gives me amazing results!

Savannah HUTTO

2 years ago

Too irritating for me, despite gradual incorporation.

Tammy Collins

2 years ago

Great product! I am not disappointed

Need to Know

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

Precautions: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered.

Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.

Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin.

Tretinoin Cream should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether.

Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.

Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate.

To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

How to Use

Morning Routine:

  • Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne.

Nighttime Routine:

  • Wash with a mild soap and dry skin gently
  • Wait 20 to 30 minutes to allow skin to completely dry
  • Squeeze no more than half an inch of medication on to fingertip; more medication will not yield faster or better results and may cause irritation
  • Apply onto face, covering affected area lightly, starting with your forehead, chin and both cheeks, then spread over the entire affected area
  • Avoid corners of the nose, mouth, eyes and open wounds
  • Tretinoin is for topical use, only. 
  • Tretinoin should be applied once daily, or as directed by physician.
  • Please ensure to always read and follow the Patient Instruction in the Prescribing Information leaflet that accompanies your tretinoin prescription.
  • Tretinoin acne treatment should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes. 
  • Application of excessive amounts of gel will not provide incremental efficacy.
  • Store tretinoin cream at controlled room temperature below 80°F

Morning Routine:

  • Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne.

Nighttime Routine:

  • Wash with a mild soap and dry skin gently
  • Wait 20 to 30 minutes to allow skin to completely dry
  • Squeeze no more than half an inch of medication on to fingertip; more medication will not yield faster or better results and may cause irritation
  • Apply onto face, covering affected area lightly, starting with your forehead, chin and both cheeks, then spread over the entire affected area
  • Avoid corners of the nose, mouth, eyes and open wounds
  • Tretinoin is for topical use, only. 
  • Tretinoin should be applied once daily, or as directed by physician.
  • Please ensure to always read and follow the Patient Instruction in the Prescribing Information leaflet that accompanies your tretinoin prescription.
  • Tretinoin acne treatment should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes. 
  • Application of excessive amounts of gel will not provide incremental efficacy.
  • Store tretinoin cream at controlled room temperature below 80°F

FAQs